In contrast, another study found that P2X7 receptor blockade by BBG increased C6 glioma cell proliferation, an effect corroborated by enhanced tumor growth observed in rats that received intracranial transplantation of C6 glioma cells either due to p2rx7 gene knockdown or pharmacological P2X7 receptor blockade (Fang et al., 2013). Here, P2RX7 is linked to central nervous system cancer.