In addition to the aforementioned effects mediated by P2X7 receptors, these receptors have also been involved in memory and cognition impairment, key symptoms of AD frequently attributed to Aβ deposits and neurofibrillary tangles, which spread from the trans-entorhinal and hippocampal regions to the primary areas of the neocortex (Raskin et al., 2015). This evidence concerns the gene P2RX7 and Alzheimer disease.