P2RX7 and neuroblastoma: In two different cellular lines (HEK293T and neuroblastoma N2a), inhibition of either constitutive expression or overexpression of the P2X7 receptor increased α-secretase activity through inhibition of glycogen synthase kinase 3 (GSK-3) (León-Otegui et al., 2011; Diaz-Hernandez et al., 2012; Miras-Portugal et al., 2015).