LAMA2 and Respiratory insufficiency: The annual rate of change in forced vital capacity (FVC) was not found to be significant in LAMA2-RD patients in this longitudinal study; however, one potential reason could be that the non-ambulatory patients with LAMA2-RD in this study may have already reached a nadir in their respiratory insufficiency, resulting in a lack of further decline during this study which took place over 4 years (Jain et al., 2019).