LAMA2-RDs are classically divided into two main phenotypic categories: a more common severe, early-onset form, presenting with features of CMD, also known as Merosin Deficient Congenital Muscular Dystrophy type 1A (MDC1A), and a much less common, milder, later-onset form often presenting with a phenotype suggestive of limb-girdle muscular dystrophy (LGMD) with prominent joint contractures. This evidence concerns the gene LAMA2 and congenital merosin-deficient muscular dystrophy 1A.