This resulted in an abnormally increased dopaminergic signaling in both the striatum (Figure 3E, p = 0.0102) and nigra (Figure 3F, p = 0.0106), as testified by an increased ratio of threonine-34-phosphorylated/total DARPP-32 in LID vs. PD rats. The gene discussed is PPP1R1B; the disease is Parkinson disease.