It has been reported that fingolimod suppressed Tnfα at both the gene level and protein expression level detected by enzyme-linked immunosorbent assay (ELISA) in vitro and in a non-diabetic stroke mice model at 24 h and 3 days after tMCAO (Liesz et al., 2011; Wei et al., 2011; Noda et al., 2013). The gene discussed is TNF; the disease is stroke disorder.