TARDBP and amyotrophic lateral sclerosis: This might become a double-edged sword approach, in which astrocytes provide neurotrophic factors and neuroprotective support through the reduction of misfolded proteins such as TDP-43 to the diseased MNs from one hand, and from other hand might become malfunctioning or even toxic, A1 reactive astrocytes, once they will be introduced to hostile environment ALS patients CNS enriched with aggregations of mis-folded proteins.