Many of the selected genes have been found to be associated with neurological diseases, including autism [SHANK2 (Monteiro and Feng, 2017; Won et al., 2012)], chronic pain [CACNG2 (Bortsov et al., 2019; Nissenbaum et al., 2010)], epilepsy [CHRNB2 (Diaz-Otero et al., 2008)], Huntington’s disease [GRIN3A (Marco et al., 2013)], and neurodegenerative diseases [SYBU (Bereczki et al., 2018)] (Supplementary Table S1). This evidence concerns the gene CHRNB2 and neurodegenerative disease.