However, the phenotypes of DEPDC5 mutations included not only familial epilepsies such as familial focal epilepsy with variable foci (Dibbens et al., 2013), autosomal dominant (AD) nocturnal frontal epilepsy (Ishida et al., 2013; Picard et al., 2014), and familial temporal lobe epilepsy (TLE) (Ishida et al., 2013; Striano et al., 2015) but also non-familial focal epilepsies, such as childhood epilepsy with centrotemporal spikes (rolandic epilepsy) (Lal et al., 2014) and epilepsy with continuous spikes and waves during slow-wave sleep (Ricos et al., 2016). Here, DEPDC5 is linked to epilepsy.