DEPDC5 gene (OMIM∗614191) encodes disheveled Egl-10 and pleckstrin (DEP) domain containing protein 5, which forms part of the GTPase-activating protein activity toward RAG complex 1, a repressor of the mammalian target of rapamycin (mTOR) signaling pathway that is closely related to epilepsies (Bar-Peled et al., 2013; Baldassari et al., 2019). Here, DEPDC5 is linked to epilepsy.