To this regard, it has been demonstrated that PACAP prevents epidermal growth factor (EGF) deprivation−induced cell death in NSC−34 cells expressing G93A SOD1 mutation, an in vitro model of ALS (Jiménez Garduño et al., 2017; Maugeri et al., 2019c). The gene discussed is ADCYAP1; the disease is amyotrophic lateral sclerosis.