Interestingly, overexpression of PACAP encoded by the ADCYAP1 in the in the oculomotor nucleus (Hedlund et al., 2010) should result in a trophic effect as demonstrated in ALS and other neurodegenerative models (Morio et al., 1996; Shintani et al., 2005; Wu et al., 2006). The gene discussed is ADCYAP1; the disease is amyotrophic lateral sclerosis.