Comparison of microarray datasets of sporadic ALS motor cortex and mutated SOD1 (mSOD1) G93A mice brains revealed that some genes, including those of PACAP and its receptor PAC1R, are deregulated in the same direction in both human and transgenic animals (Morello et al., 2017b). This evidence concerns the gene ADCYAP1 and amyotrophic lateral sclerosis.