Machine learning techniques have recently been used to predict treatment potential in two forms of Leber congenital amaurosis (LCA) caused by mutations in CEP290 or IQCB1 (NPHP5), that had little or no measurable vision but some measurable central retinal structure (Sumaroka et al., 2019). This evidence concerns the gene CEP290 and Leber congenital amaurosis.