TSPO and early-onset autosomal dominant Alzheimer disease: More recent and debated observations, however, argued the significance of TSPO in steroidogenesis and evidenced its involvement in pathological conditions, like inflammation, apoptosis and neurological diseases (e.g., Alzheimer’s disease or multiple sclerosis); indeed, TSPO seems to be expressed only in response to insults and pathological states (Bonsack and Sukumari-Ramesh, 2018).