Neurotoxins that mimic PD symptoms, such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), increase the activity of the Cav1.3 channel by downregulating the expression of TRPC1, which lead to a decrease in SOCE and the release of Ca2+ from ER to the cytosol in DNs and mesenchymal stem cells (Sun et al., 2018). This evidence concerns the gene TRPC1 and Parkinson disease.