MTOR and bone cancer: Studies show that blocking mTOR at the peripheral level, spinal level or supraspinal level alleviated pain-related behaviors associated with inflammation, neuropathic pain, or bone cancer pain (Jimenez-Diaz et al., 2008; Asante et al., 2009; Geranton et al., 2009; Obara et al., 2011; Lyu et al., 2013; Zhang et al., 2013, 2019; Cui et al., 2014; He et al., 2016, Jiang S.P. et al., 2016; Zarpelon et al., 2016; Kwon et al., 2017; Kondo et al., 2018; Liu et al., 2019; Kim et al., 2020; Choi et al., 2020; Xing et al., 2020).