ATXN3 and Spinocerebellar ataxia type 3: In line with previous findings of decreased NAA/Cr ratios in the cerebellum (Lirng et al., 2012; Wang et al., 2012; Lopes et al., 2013; Chen et al., 2014; Huang et al., 2017; Peng et al., 2019) and deep WM (D’Abreu et al., 2009), a recent meta-analysis has also demonstrated a decrease in the NAA/Cr ratio in the cerebellum of SCA3/MJD patients compared to that of normal controls (Krahe et al., 2020).