The corticotropin-releasing hormone (CRH) family consists in vertebrates of five structurally related neuropeptides that are involved in the regulation of physiological response to stress, emotional behavior, and anxiety (Vale et al., 1981; Dunn and Berridge, 1990; Koob and Heinrichs, 1999; Lovejoy and Balment, 1999; Gysling et al., 2004; Fox and Lowry, 2013). This evidence concerns the gene CRH and Anxiety.