The high level of CTHRC1 is connected with the progression and metastasis of pancreatic cancers through the activation of several key signaling molecules, including the steroid receptor coactivator (Src), FAK, paxillin, MEK, ERK, and Ras-related C3 botulinum toxin substrate 1 (Rac1) [77]. Here, CTHRC1 is linked to familial pancreatic carcinoma.