CTHRC1 and cancer: The components form a CTHRC1-Wnt-Fzd/ROR2 complex to activate the Wnt/PCP pathway selectively and transmit signals from the cell-surface complex to the nucleus by Dvl-RhoA/Rac1-JNK-ATF2/c-Jun cascade, promoting cancer cell protrusions, proliferation, migration, and invasion [14, 76, 93–98].