In the absence of Wnt signaling, the cytoplasmic β-catenin form the “destruction complex” composed with the casein kinase 1α (CK1α), glycogen synthase kinase 3β (GSK3β), adenomatous polyposis coli (APC), and Axin, which activates the EMT to promote cancer invasion and metastases through CTHRC1/Wnt/β-catenin [76, 77]. The gene discussed is CTHRC1; the disease is cancer.