HTR5A and autism: Interestingly, increased 5-HT signaling in nucleus accumbens has rescued social deficits in a preclinical model of autism [68], and while coordinated signaling of 5-HT and oxytocin in the nucleus accumbens has been reported to be required for the reinforcement of social interaction [69], investigations of oxytocin and 5-HT indicate a different pattern of interaction in subjects with ASD compared with controls [31, 70–72].