Bioinformatic analysis of GSE71729 dataset also evidenced that MRP4 is upregulated in 17 established pancreatic cancer cell lines compared to tumor and peritumor samples (p < 0.001), suggesting that elevated expression of MRP4 is associated with the process of carcinogenesis and may confer an adaptive phenotype to cells growing in culture. This evidence concerns the gene ABCC4 and familial pancreatic carcinoma.