To reconcile the discrepancy, we treated a mouse B-cell lymphoma cell line derived from Eu-Myc mice with RC-1 in vitro and found that the maximum BTK degradation is only 30–40% even dosed up to 25 μM of RC-1 (Supplementary Fig. 9), indicating that RC-1 is indeed much less potent for BTK degradation in mouse cells than human cells. The gene discussed is CBX8; the disease is B-cell non-Hodgkin lymphoma.