ERBB2 and breast cancer: In a study recently published in Nature Communications, de Groot et al. reported the results of the phase II trial “DIRECT”, in which experimental cyclic fasting-mimicking diet (FMD) in combination with standard anthracycline-taxane preoperative chemotherapy (ChT) failed to reduce ChT-related adverse events and to improve the rate of pathological complete responses (pCR) in patients with stage II–III HER2-negative breast cancer (BC)1.