EPHA2 and nasopharyngeal carcinoma: Moreover, CCK-8, plate colony formation, and EdU incorporation labeling assay showed that Erk-2 overexpression restored the proliferation and anchorage-independent growth of NPC cells expressing EphA2-YA (Fig. 5a–e) and CCK-8 assay showed that MEK inhibitor U0126 inhibited the proliferation of NPC cells expressing EphA2-WT in a dose-dependent manner (Fig. 5f).