In summary, we found that ligand-independent pY772-EphA2 is responsible for EphA2-dependent NPC cell growth in vitro and in vivo by activating the Shp2/Erk-1/2 signaling pathway and pY772-EphA2 is a target of ALW-II-41-27 in the NPC cells (Fig. 7e). This evidence concerns the gene MAPK3 and nasopharyngeal carcinoma.