EPHA2 and nasopharyngeal carcinoma: Therefore, we detected the effect of pY772-EphA2 on AKT/Stat3 signaling activity in the NPC cells and observed that EphA2-Y772A did not affect the phosphorylated levels of AKT and Stat3, whereas EphA2-S897A reduced the phosphorylated levels of AKT and Stat3 as compared to endogenous EphA2-WT (Supplementary Fig. 1), indicating that pY772-EphA2- and pS897-EphA2-activating oncogenic signaling pathways are different in the NPC cells.