Moreover, western blotting and immunohistochemistry (IHC) showed that EphA2-WT increased the levels of p-Shp2 and p-Erk-1/2 in the xenografts of NPC cells, whereas EphA2-YA failed to do it as compared to endogenous EphA2 knockdown (Fig. 3e, f). This evidence concerns the gene PTPN11 and nasopharyngeal carcinoma.