Therefore, we determined whether pY772-EphA2 activates Shp2/Erk-1/2 signaling pathway in the NPC cells and demonstrate that pY772-EphA2 mediates EphA2-activating Shp2/Erk-1/2 signaling pathway in the NPC cells and xenografts. The gene discussed is MAPK3; the disease is nasopharyngeal carcinoma.