Intratumoral treatment with a synthetic cyclic diadenyl monophosphate (CDA) derivative to activate the signaling adaptor Stimulator of Interferon Genes (STING) led to long-term tumor-free survival of mice with relatively immunogenic tumors such as B16 melanoma.11 CDA treatment induced dendritic cells (DCs) to release interferon type I (IFN-I) and cross-present antigens to activate effector CD8 T cells. The gene discussed is STING1; the disease is melanoma.