COX2 expression increases in the TME during LLC tumor growth and COX2 inhibitors slow LLC tumor growth.13 14 Direct CDA treatment potentiated COX2 gene transcription rapidly in tumor lesions and TDLNs, and elevated COX2 transcription persisted for over 6 hours in both TME sites (figure 2C, D). This evidence concerns the gene PTGS2 and neoplasm.