METTL3 and Alzheimer disease: This, accompanied by an elevated level and redistribution of METTL3 expression in AD hippocampal tissue, likely represents abnormal misfolding and/or aggregation of METTL3, perhaps resembling the frequent aggregation of RNA-binding proteins in neurodegenerative disorders (Arai et al., 2009; Conlon and Manley, 2017).