METTL3 and Alzheimer disease: Given that several m6A regulatory proteins are subjected to post-translational ubiquitination and SUMOylation (Zhang et al., 2015; Tai et al., 2017; Du et al., 2018; Zhu et al., 2018; Liu et al., 2020; Xu et al., 2020), it is conceivable that dysregulation of the ubiquitin-proteasome system may contribute to the aggregation of METTL3 in AD (Ihara et al., 2012; Zheng et al., 2016).