MARVELD2 and SATB2 associated disorder: The carrier frequencies of the prevalent variants in SAS: NFE populations are: 0:0.0018% for MANBA, 0.875%:0.009% for GJB2 and 0.039%:0.005% for MARVELD2. In the both prevalent variants from Asia (GJB2 and MARVELD2), the frequency of SAS is by 1–2 orders higher compared to NFE.