MANBA and hearing loss disorder: Interestingly, this subject was detected to have two different autosomal recessive causes of hearing loss since besides having a homozygous c.2158-2A>G MANBA variant he is also a homozygote for the c.71G>A (p.W24*) variant in GJB2. His hearing-impaired mother (SK7 – II/2) is a heterozygote for the c.2158-2A>G variant and she had several other relatives suffering from hearing loss, who were not available for genetic testing.