INS and type 2 diabetes mellitus: The Spanish primary care RedGDPS algorithm for blood glucose lowering therapy in adults with type 2 diabetes recommends the use of metformin as an initial intervention followed by dual therapy (metformin plus either dipeptidyl peptidase-4 inhibitor, glucagon-like peptide-1, sodium–glucose cotransporter 2 inhibitors or sulfonylurea) and then triple therapy (metformin plus combinations of other therapies), before progression to insulin-based treatment [11].