In conclusion, the reduced ability to secrete motogen factors, to efficiently contract collagen matrices, together with the increased CAV-1 and decreased α-SMA expression markers, indicates that Pep 1 and Pep 2 decapeptides induce a partial reversion of the CAF-like phenotype of TIFs, resulting in an overall impairment of fibrosarcoma cells invasion in 3D-organotypic co-cultures. This evidence concerns the gene CAV1 and fibrosarcoma.