CDKN1A and prostate cancer: Among them are CyclinD, whose inhibition may cause apoptosis in colorectal cancer cells [28], p53, that leads to the upregulation of p21Cip1/WAF1, GADD45, and 14-3-3 proteins to cause cell cycle arrest [74], RB1, which prevents the metastasis of prostate cancer [75], and others [6].