THOP1 and melanoma: The role of THOP1 in the production of the PRAME (PRA190–198), an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C and a clinically important epitope of the melanoma protein MART-1 epitopes, was in accordance with an independent description that THOP1 can both destroy and generate peptides of the HLA class I ligand lengths [38].