However, when venetoclax was combined with IACS-010759, it completely abolished the sequestration of cytochrome c induced by IACS-010759, leading to an increase in cytochrome c in the cytosolic fraction, suggesting that this is the main mechanism underlying the synergy between the two agents in OXPHOS-reliant AML cells (Figure 5). This evidence concerns the gene CYCS and acute myeloid leukemia.