CD8A and neoplasm: A third, special form of antigen-presentation can be seen (not exclusively, but most prominently) in a subset of DC: it is termed cross-presentation and is characterized as the capacity to present an external, phagocytosed antigen in the complex with MHC-I molecules to CD8+ T cells [7], thereby sensing the tumor- (or virus-) specific antigens and exposing them to induce an effective cytotoxic antitumor response [8].