To identify all the molecular alterations that MDK promoted during the migration of NSCLC cells, we analyzed by western blotting under the same condition as shown in Figure 4A. MDK expressed under hypoxia decreased Notch2 levels and induced Notch2 intracellular domain (NICD) cleavage, which is the active form of Notch2. This evidence concerns the gene NOTCH2 and non-small cell lung carcinoma.