All the cancer cells used in our study, H1299, A549 (NSCLC), Hep3B, HepG2 (HCC), HCT116, CT26 (Colon cancer), MCF-7, MDAMB231 (Breast cancer), MKN1, MKN5 (Gastric cancer), U87MG, SHSY5Y (Brain cancer), and SKOV3, SNU840 (Ovary cancer), expressed mRNA and proteins of HIF-1α and HIF-2α (Figures S1 and S2) under hypoxic conditions. Here, EPAS1 is linked to colonic neoplasm.