MDK-induced NF-κB also increased cancer cell proliferation through PI3K-Akt signaling and Hes1 triggered epithelial-to-mesenchymal transition via increased Vimentin and Snail levels, and decreased E-cadherin levels, which were not recovered by survivin expression under MDK knock down and hypoxia (Figure S11). The gene discussed is HES1; the disease is cancer.