MDK and neoplasm: To confirm the in vivo benefit of inhibiting MDK in an MDK-expressed lung tumor model, we constructed a xenograft in vivo model with H1299 cells, which stably expressed the empty vector (E.V.)and MDK genes because all tumor tissue could be exposed by hypoxia and we needed to check the MDK effects of the -pro-tumor, EMT, and angiogenesis via gain-of-function study (Figure 5A and Figure S6).