While 18F-FDG clearly is the standard of reference tracer in nuclear imaging of MM, scan results might be influenced by different factors, such as expression levels of hexokinase-2 and glucose transporter, as well as hyperglycemia, and false-positive results due to infection, chronic inflammation, metallic implants, surgery, and fracture healing can occur [2,19,20,21,22]. The gene discussed is HK2; the disease is Hyperglycemia.