CXCL13 and osteosarcoma: Incubation of all three osteosarcoma cell lines with PLCβ, PKCα, and c-Src inhibitors (U73122, GF109203X, and PP2, respectively) antagonized CXCL13-induced increases in cell migration and VCAM-1 production (Figure 4A–C and Figure S3A,B).