CCND1 and lip and oral cavity carcinoma: In addition to CCND1/cyclin D1 and CTTN/cortactín [14,15], FADD has been proposed as a potential 11q13 amplicon driver (i.e., an amplified gene invariably found to be amplified and overexpressed, for which overexpression confers advantages to the host cell and contributes to the maintenance of the malignant phenotype) in human [16], larynx [17] and oral cancer [7].