FADD and metastatic malignant neoplasm in the lymph nodes: N status: A significant association was found among FADD alterations and positive-lymph node metastasis (odds ratio [OR] = 2.07, 95% CI = 1.47–2.91, p < 0.001), although a certain degree of heterogeneity was found (p = 0.008, I2 = 55.2) (Figure 2).