Through NOTCH inhibition, FADD exerts a differentiation-suppressing and proliferation-stimulating effect on tumour cells; furthermore, this pro-proliferative action of FADD is also exerted by activating the NF-kB and MAPK (Ras-Raf-MEK-Erk) pathways, both potent regulators of cyclin D1 expression, essential in the regulation of proliferative endpoints in HNSSC [9,14]. This evidence concerns the gene FADD and neoplasm.