Among a total of 3491 deregulated genes found, FADD was identified as one of the “top 5” more frequently altered HNSCC genes (CDKN2A, deleted in 32.03% of patients; CDKN2B, deleted in 28.34% of patients; PPFIA1, amplified in 26.02% of patients; FADD, amplified in 25.63% of patients; and ANO1, amplified in 25.44% of patients-) [19]. The gene discussed is ANO1; the disease is head and neck squamous cell carcinoma.