FADD and neoplasm: Another five variables showed a significant positive association with high histological grade (FADD amplification: p = 0.006 [32]; overexpression: p = 0.01 [30]), high tumour thickness (FADD amplification: p = 0.02 [30]) and perineural invasion (FADD amplification and overexpression, p = 0.04 and 0.007, respectively, [30]).