The most common corresponding clinical symptoms of infection are generally similar to those of other bacterial pyogenic meningitis, including include headache, fever, vomiting, subjective hearing impairment, positive meningeal sings, the presence of skin rash, bacteremia, shock, acute renal failure, respiratory distress, MOF, changes in the common laboratory parameters (leukocytes, platelets, C-reactive protein) and findings in the CSF [1,4,38,51,52,53]. Here, CRP is linked to acute kidney injury.