The consequences of an increased HIF-1α activity comprise an altered protein expression involved in angiogenesis, metabolic reprogramming, extracellular matrix (ECM) remodeling, epithelial mesenchymal transition (EMT), motility, invasion, metastasis, cancer stem cell maintenance, immune evasion, metabolic adaptations, as well as immunologic changes of the tumor microenvironment (TME) during early carcinogenesis, which have been recently reviewed in detail [3,8,9,10,11,12,13]. Here, HIF1A is linked to cancer.