Considering that EGFR signaling plays a key role in lung cancer progression, and that EGFR-targeted therapies represent effective approaches for the clinical treatment of lung tumors [23,24,25,26], studying the interplay between BoHV-1 infection and EGFR signaling with an emphasis on A549 cells is important not only in understating virus replication mechanisms but also in elucidating its oncolytic mechanisms. Here, EGFR is linked to lung cancer.