Our study showed that MIR129-2, MIR1296, MIR219A1, MIR29B1, MIR375, MIR411, and MIR431 are downregulated in the cortex of AD patients, while MIR199A2, MIR218-2, MIR24-2, MIR92A1, and MIR99A are upregulated. Here, MIR218-2 is linked to Alzheimer disease.