GRM4 and major depressive disorder: The changes in miR-1202 levels in MDD is notable because one of its predicted targets is RNA encoding the metabotropic glutamate receptor 4 (GRM4) and the G-allele in the GRM4 SNP rs2229901, which is located within the miR-1202 binding site of the GRM4 coding sequence, is associated with an increased risk of MDD.