IGHE and Alzheimer disease: Our OVA exposed mice successfully captured the characteristics of AD (i.e., increase in serum IgE, mast cell infiltration in the dermis, elevated gene expression of CHIL1 (related to Th2 response), FCER1A (Fc fragment of IgE receptor 1a), IL-33 (an epithelial cell-derived cytokine that promotes Th2 cytokine responses), and RNASE2A (important for eosinophil recruitment and function)).