IGHE and allergic disease: The enhancement of the allergic immune response by PM is characterized by increased mast cells in the dermis, elevated serum IgE level, upregulated expression of the skin barrier genes (epidermal differentiation complex; protease; antimicrobial response), pro-inflammatory genes, and allergy genes (microarray: IL-13RA1, IL-33, FCERIG, CHIL1; RT-PCR: IL-13; KEGG analysis: Th17 cell differentiation, IL-17 signaling pathway).