AHR and pulmonary arterial hypertension: The ligation of AHR by xenobiotic small chemicals (i.e., PAH, dioxin) was reported to preferentially affect the differentiation and propagation of Th 17 cells [31,36,37], as seen in our PM exposed mouse models (enrichment of upregulated DEGs in the Th17 cell differentiation (mmu04659), and IL-17 signaling pathway (mmu04657)), which too suggests that the PAH-AHR axis underlies the allergic response to PM.