Among them, Astragalus iv and Astragalus polysaccharides in Astragalus can reduce the damage of renal tubules and podocytes, inhibit renal interstitial fibrosis.[18–20] Hirudus can improve renal microcirculation, reduce ischemia-hypoxia damage in DKD rats.[21] Catalpa in radix rehmanniae can inhibit the expression of Grb10 and improve the renal function injury of DKD rats.[22] Therefore, it's essential to do the meta-analysis of currently published studies to assess the effectiveness of QZJT capsule for treating DKD. This evidence concerns the gene GRB10 and diabetic kidney disease.