In the past few years, an increasing number of studies have focused on the immune response of the body to the tumor, and the detection of autoantibodies to tumor-associated antigens has been carried out in which the highest focused point is the anti-p53 antibody in various cancers.[15] As a tumor suppressor gene, the mutation of the p53 gene is found not only in HCC but also in many other cancers. The gene discussed is TP53; the disease is cancer.