Some studies show that the HCV core protein gene can induce the mutation of the p53 gene and HCV Core protein can be involved in the regulation of p53 gene expression, which leads to the generation of abnormal p53 protein in human body.[42] We found that the HCV infection rate in Egyptian patients with liver disease leads to a relatively high positive rate, which is an important reason for the impact of heterogeneity.[21,24,43,44] Simultaneously, HBV was one of the most high-risk factors of HCC which infected about 90% HCC patients in Asia especially China. Here, TP53 is linked to infection.