However, p53 gene mutations caused by various reasons can lead to the accumulation of abnormal p53 protein,[11] which act as antigens that may produce different levels of anti-p53 antibodies in serum, tissue, cell, and other body fluids.[12] According to the report, the proportion of the p53 mutations and anti-p53 antibody positive is more than 50% in patients with HCC.[4,13]. This evidence concerns the gene TP53 and hepatocellular carcinoma.