Along with the increase of the studies, many researchers began to focus on the detection of anti-p53 antibody in liver cancer, but they have varying results.[14,15] In the present study, we try to gather the whole studies on the detection of anti-p53 antibody by conducting a systematic review and meta-analysis to evaluate the diagnostic value of hepatocellular carcinoma. The gene discussed is TP53; the disease is hepatocellular carcinoma.