LDLR and familial hyperaldosteronism: In 2001, another Spanish group, Chaves et al, conducted a study aiming to ascertain if the molecular analysis of LDLR helped in predicting the response to simvastatin in heterozygous FH individuals.[10] They provided total cholesterol and LDL-c levels for a group of subjects with FH and different LDLR mutations, including class 3 defective mutations such as LDLR c.902A>G:p (Asp301Gly).