The parameters predicting better recurrence-free and overall survivals in patients with HCC than their counterparts were the values of emPAI% of alpha-2-HS-glycoprotein ≥0.2%, apolipoprotein CIII ≥0.2%, Ig lambda chain VI region NEWM ≥1.0%, and serum amyloid P component ≥0.3% (S3 Fig). This evidence concerns the gene APOC3 and hepatocellular carcinoma.