In terms of HCC-related mortality, the lower HRs in the AFP group than in the AFP+US group were also significant, as shown in Table 4 (adjusted HR [95% CI], 0.55 [0.41–0.75], P<0.001 in Model 1, and HR 0.62 [0.46–0.84], P = 0.002 in Model 2). The gene discussed is AFP; the disease is hepatocellular carcinoma.