We also point out that the NaV1.2 and NaV1.6 databases included cases of varying severity (e.g., from benign cases to those with developmental and epileptic encephalopathy), For the NaV1.1 database, we were able to separate missense variants Dravet Syndrome patients from patients with milder forms of epilepsy (n = 83). This evidence concerns the gene SCN2A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.