Rabkin et al. reported (McIntire, Chen, Sood, & Rabkin, 2014) that acute uremia induces resistance to leucine‐stimulated anabolic signaling based on the relative changes in the phosphorylation of mTOR and downstream proteins such as eukaryotic translation initiation factor 4E‐binding protein 1 (4E‐BP1) and S6K, 44 hr following bilateral ureteral obstruction. Here, RPS6KB1 is linked to uremia.