PPARGC1A and acute kidney injury: No differences were observed in the LC3 II/I ratio, a marker of autophagy activation, between the AKI and sham‐operated groups (Figure S4); however, mRNA expression of peroxisome proliferator‐activated receptor gamma coactivator 1α (PGC‐1α) was decreased by 0.59‐fold on day 1 in the AKI group (p < .05; Figure 7c).