AKT1 and acute kidney injury: In the AKI group, myostatin mRNA expression was significantly upregulated by 1.92‐fold on day 1 (p < .05) and 4.26‐fold on day 7 (p < .0001; Figure 6a,b), whereas the ratio of phosphorylated Akt (p‐Akt) to total Akt protein was significantly downregulated by 0.39‐fold on day 7 (p < .01; Figure 6c).