Immunohistochemical staining demonstrated that miR-146b-5p antagomir treatment significantly decreased the expression of collagen type 1 and increased the number of CD31+ microvessels in the porcine MI heart, from 70.50 ± 12.80 to 26.86 ± 6.35 (P = 0.0001) and 24.92 ± 4.59 to 64.67 ± 7.74 (P = 0.0001), respectively, when compared with the Anti-Ctrl group (Fig. 5F and 5G). Here, PECAM1 is linked to myocardial infarction.