MUC16 and neoplasm: MUC16 has previously been implicated in tumor cell proliferation, metastasis, and modulation of the innate immune response by direct suppression of natural killer cell function.3,4 Also, our GSEA analysis revealed that 8 biological processes regarding cell proliferation, immune response, and mTORC1 signaling were significantly upregulated in MUC16-mutated tumors, providing biological insights concerning the link between MUC16 mutation and ICI response.