These results were intriguing in light of the knowledge that laminin 5-1-1 is required for HF downgrowth and SHH signaling (Fleger-Weckmann et al., 2016; Gao et al., 2008), and that Lama5 and Lamac1 were among the most highly modified and efficiently translated mRNAs in skin (Figure 1G). Here, SHH is linked to hydrops fetalis.