These results were intriguing in light of the knowledge that laminin 5-1-1 is required for HF downgrowth and SHH signaling (Fleger-Weckmann et al., 2016; Gao et al., 2008), and that Lama5 and Lamac1 were among the most highly modified and efficiently translated mRNAs in skin (Figure 1G). This evidence concerns the gene LAMA5 and hydrops fetalis.