Further signs that WNT signaling was deleteriously affected included the promotion of sebaceous gland fate characteristics at the expense of HF fate ones (Merrill et al., 2001; Niemann et al., 2003), the perturbations in SHH signaling and also the difficulty that Mettl3 null HFs seemed to face in engulfing the DP. This evidence concerns the gene SHH and hydrops fetalis.