In this regard, in a breast cancer cell line, METTL3 was found to mark pri-miRNAs for recognition and processing (Alarcón et al., 2015), and in skin, METTL3 depletion shares certain similarities with global loss of miRNAs (Yi et al., 2008; Yi and Fuchs, 2011). This evidence concerns the gene METTL3 and breast carcinoma.