HGPS and other related disorders such as Emery–Dreifuss muscular dystrophy, Limb–Girdle muscular dystrophy and congenital muscular dystrophy can also lead to severe muscle pathologies resembling muscle weakness in old age, suggesting how modifications in the nuclear envelope may alter skeletal muscle development and function. This evidence concerns the gene ZMPSTE24 and congenital muscular dystrophy due to LMNA mutation.