EMD and Emery-Dreifuss muscular dystrophy: The lack of effect on muscle function in Emerin-null mice is unlike the human EDMD phenotype, and may be explained by Lamina-associated polypeptide 1 (LAP1) compensation; LAP1 is highly expressed in mouse compared with human skeletal muscle, and reducing LAP1 expression in Emerin-null mice induced muscle abnormalities [97].